ISSN: 1223-1533

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Authors: DY Ilina, TE Tulintseva, EA Tsurinova, TV Treshkur


The aim of the study is to define the possibility of treatment idiopathic ventricular arrhythmia (VA) with anxiolytic in patients with anxiety.


Methods: Inclusion criteria were an abnormal amount of idiopathic VA during the Holter ECG, the medium or high anxiety level according to psychological questionnaires. All patients underwent a clinical examination, ECG, echocardiogram, ETT, psychological questionnaires, psychological counseling, emotional Stroop Color and Word Test (SCWT).

There were two groups out of 56 patients. Group I included 20 patients (12 women), mean age 46.6±14,7 years, with ventricular ectopic complexes (VEC) in an amount 11354,7 ± 536,3 / day, which received anxiolytic in a therapeutic dose for 30 days. Control group consisted of 20 patients (11 women), 45,2±11,3 years, VEC 12467,2 ± 423,1 /day, without any therapy. Holter ECG, SCWT and psychological questionnaires were re-conducted in 30 days.


Results: The  average  number of VEC decreased significantly from 478,8 ± 47,2 to 155,7 ± 73,2 (temp = 2.4, p : 0,05) in the first group according to Holter ECG, while in the control group - from 512,5 ± 67,5 to 467,3 ± 39,4 (temp = 0.5, p 0,05). Positive SCWT became negative in 95% of patients in the first group, i.e. arrhythmia was not provocated (cemp = 3.1, p : 0,01). The number of patients with middle and high anxiety level has decreased more than 3  times  (cemp  =  1.85,  p:0,05),  after  therapy with anxiolytic. There were no significant changes in the second group in the results of questionnaires and SCWT.


Conclusions: This study shows that psychogenic factors play an important, and sometimes - a decisive role in the genesis of idiopathic VA. Anxiolytic can be recommended to patients with VA and high anxiety level.