ISSN: 1223-1533

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Authors: O. Grosu, S. Odobescu, G. Corcea, I. Moldovanu


Introduction: Heart rate variability (HRV) is a useful tool to evaluate autonomic cardiovascular activity in different pathologies including migraine. Reduced HRV over 24 hours predicted an increase in cardio-vascular morbidity.


Objectives: to evaluate and analyze autonomic imbalance in cardiovascular activity by mean of HRV in migraine patients.


Methods: Study group consists of 65 pts with migraine which underwent 24- hour ambulatory ECG monitoring with evaluation of HRV. Time domain parameters evaluated were: VAR, CBBP, avNN, SDNN, RRNN, SDANN, SDNN index, RMSSD and pNN50 % and frequency domain: LF, HF and VLF. All expressed as mean, day time and night time values. All the data were analyzed using SPSS statistical package for Windows.


Results: Study sample included 40 pts with chronic (CM) and 25 pts with episodic migraine (EM), mean age 47.7±11.29 (CM) and 47.6±12.6 years (EM). CM had increased VAR (946.8±433.4 vs. 785.6±214.4, p<0.05), SDNN index (53,1±17.8 vs. 45.7±8.6, p<0.05) and VLF (2013.05±1151.5 vs. 1567.32±526.6, p<0.05).

In the middle age (40-50 years old) EM had increase Heart rate (84.8±8.6 vs. 77.5± 7.9, p<0.05) and CM increase: avNN (837.6±93.7 vs. 787.0±78.3, p<0.05), SDNN index (60.1±15.0 vs. 45.8±5.63, p<0.05) and VLF

(2724.4±1449.1 vs. 1618.2±509.9, p<0.05). In the advanced age (50-59 years old) CM had increase HF (30.6±13.1 vs. 19.7±11.9, p<0.05).

Compared between groups (EM40-50 vs. EM 50-59) - EM50-59 had reduced pNN50% and CBBP and CM 50-59 reduced pNN50%, SDNN index, VLF, LF, HF but increased HF(%).


Conclusions: CM patients presented increased HRV and parasympathetic activity compared with EM in whole study sample and in the 40-50 age group but just parasympathetic activity in the 50-59 age groups. Older CM patients presented more reduction in total HRV, sympathetic and parasympathetic influence (day time), except HF (%) night time which reflect strong vagale influence probably as a consequence of chronification process.