DETERIORATION HEART RATE TURBULENCE FINDING OF CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN MULTIPLE SCLEROSIS
Introduction: Heart rate turbulence is the baroreflex-mediated vagal and sympathetic short-term oscillation of cardiac cycle lengths after spontaneous premature ventricular contractions. Multiple sclerosis can cause sympathetic dysfunction in autonomic cardiovascular functions. Cardiovascular autonomic neuropathy has been reported in patients with multiple sclerosis by heart rate variability. However, there is no study about heart rate turbulence in multiple sclerosis patients. In this study, we aimed to determine the heart rate turbulence of multiple sclerosis by 24-h Holter monitorization.
Methods: We examined 30 patients (6 males and 24 females, mean age 33,7 ±10,1, range 21-57 years) with multiple sclerosis. Thirty healthy volunteers served as controls (mean age 35,5±6,3 years, 14 males and 16 females). ECG Holter recordings (HRT View Version 0.60-0.1, Munich, Germany) of patient and control groups were examined. HRT indices (turbulence slope [TS] and turbulence onset [TO]) were calculated from 24-h ambulatory electrocardiographic recordings.
Results: No differences were observed in blood pressure, heart rate, left ventricular diameters and ejection fraction in patients with multiple sclerosis patients, compared to the controls. There were no statistically significant differences in TO and TS between the multiple sclerosis and control groups (TO: -0.005 ± 0,029% vs 0,004 ± 0,043%; TS: 9.723 ± 6.4 ms/RR vs 11.335 ± 7,477 ms/RR, respectively).