AGE DEPENDENCY OF NOVEL REPOLARIZATION PARAMETERS
Background: The transmural dispersion of repolarization asdescribed only by QT duration does not reflex the complexity of this process.The new computer-based parameters, describing multidimensialview of repolarization, might be useful for evaluation of repolarization; however, there are limited data regarding the normal values and changes over lifetime.
Objectives: We aimed to assess normal standards and their age dependency of various new computer-based repolarization parameters. Methods:Twenty-minute high-resolution ECGs were recorded in healthy volunteers and the comprehensive analysis of the repolarization signal was employed. The following scalar parameters were studied: repolarization duration (QT, TpTe), length (Tl), amplitude, ascending and descending slope of the T wave (Tamp, aL, aR). Principal Component Analysis was applied to obtain multidimensial view of repolarization and two groups of novel parameters were computed: based on T-loop preferential plan- repolarization duration (QT, QTa,), complexity(A2/A1, A3, MV) and early/late repolarization duration (ERD, LRD,TRD) and based on eigenvector 1 – T wave duration and morphology (LST, RST).
Results: Results are shown in Table 62.1.
Conclusions: In present study, age-related norms of the new computer-based repolarization parameters were recommended. There were statistically significant differences in duration of repolarization as well as in morphology of T wave. Thus in older patientsrepolarization should be evaluated more carefully taking age into account.