ISSN: 1223-1533

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AGE DEPENDENCY OF NOVEL REPOLARIZATION PARAMETERS


Authors: Katarzyna Piotrowicz, Martino Vaglio, Jean Philippe Couderc, Jean Xio, Wojciech Zareba




 

Background: The transmural dispersion of repolarization asdescribed only by QT duration does not reflex the complexity of this process.The new computer-based parameters, describing multidimensialview of repolarization, might be useful for evaluation of repolarization; however, there are limited data regarding the normal values and changes over lifetime.

 

Objectives: We aimed to assess normal standards and their age dependency of various new computer-based repolarization parameters. Methods:Twenty-minute high-resolution ECGs were recorded in healthy volunteers and the comprehensive analysis of the repolarization signal was employed. The following scalar parameters were studied: repolarization duration (QT, TpTe), length (Tl), amplitude, ascending and descending slope of the T wave (Tamp,  aL,  aR).  Principal  Component  Analysis  was applied to obtain multidimensial view of repolarization and two groups of novel parameters were computed: based on T-loop  preferential  plan-  repolarization  duration  (QT, QTa,),   complexity(A2/A1,   A3,   MV)   and   early/late repolarization duration (ERD, LRD,TRD) and based on eigenvector 1 – T wave duration and morphology (LST, RST).

 

Results: Results are shown in Table 62.1.

 

 

Table 62.1.

 

 

Conclusions: In present study, age-related norms of the new computer-based repolarization parameters were recommended. There were statistically significant differences in duration of repolarization as well as in morphology of T wave. Thus in older patientsrepolarization should be evaluated more carefully taking age into account.