ISSN: 1223-1533

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EVALUATION OF BARORECEPTORS SENSITIVITY IN YOUNG ADULTS WITH VASOVAGAL SYNCOPE IN LONG TERM FOLLOW-UP AFTER CORRECTION OF D-TRANSPOSITION OF GREAT ARTERIES BY SENNING ATRIAL SWITCH.


Authors: Artur Z. Pietrucha, B. J. Pietrucha, Irena Bzukala, Joanna Jedrzejczyk-Spaho, D. Mroczek-Czernecka, Ewa Konduracka, Olga Kruszelnicka, Jadwiga Nessler




 

The aim of study: evaluation of baroreceptors sensitivity in relation to presence of reflex syncope in young adults with benign forms of sinus node dysfunction (SND) in near-asymptomatic young adults after reparation of d-transposition of great arteries d-TGA by Senning atrial switch (SAS) .

 

Study population: we observed 21 pts (14 men) aged 18-21 yrs with d-TGA, with electrocardiographic signs of SND and history of presyncope and 21 sex and age matched healthy volunteers.

 

Methods: All pts underwent head-up tilt test (HUTT) and transoesophageal atrial stimulation for evaluation of corrected sinus node recovery times (CNRT) before and after pharmacological blockade (PHB). CNRT>525 ms was assumed as abnormal. Non-invasive evaluation of baroreceptor sensitivity (BRS) during HUTT was evaluated in dTGA patients and healthy control group using NEXFIN analyser.

 

Results: HUTT was positive in 6 pts (28,6%), negative in 7 pts, and doubtful (presence of bradycardia and/or hipotonia with aggravated  prodroms) in 8 pts.

Mean CNRT value was 698,2ms; SACT- 124,4ms and shorten significantely after PHB (CNRT to 362,8; SACT to 116,5ms). Mild prolongation of CNRT (<850 ms) with normalization after PHB was observed in 12 pts (57,1%). Reduction of BRS was observed in dTGA pts. in comparison to healthy controls. Significant depletion of BRS was also observed in pts. with negative HUTT in relation to non-fainter, both in dTGA(systolic BP: 11,4 vs 16,9 ms/mmHg; diastolic BP 18,4 vs 21,1 mmHg;p<0,03) and control groups(systolic BP: 12,6 vs 19,4 ms/mmHg; diastolic BP 13,3 vs 16,6 mmHg;p<0,02).

 

Conclusions: Reflex vasovagal syncope frequently occurs after physiological correction of d-TGA. Electrocardiographic signs of sinus node dysfunction rather then   abnormal   electrophysiological   parameters   were noticed in near-asymptomatic young adults after reparation of d-transposition of great arteries by Senning atrial switch Significant  reduction  of  baroreceptor  sensitivity  was observed after dTGA correction by atrial switch both in pts. with positive and negative HUTT.