ROLE OF ATP-SENSITIVE POTASSIUM CHANNELS IN ARRHYTHMOGENESIS
ATP-dependent potassium (KATP) channels couple cellular metabolism to membrane excitability and function in a wide range of tissues, including the myocardium. In the heart, KATP channels are currently view as a collection of structurally related but functionally distinct ion channels mostly activated during myocardial ischemia. Two populations of cardiac KATP channels (sarcolemmal and mitochondrial) have been shown to protect the ischemic myocardium via distinct mechanisms. The presentation highlights the current knowledge concerning the pharmacological modulation of KATP channels activity as truly ischemia selective treatment modality.