BORDERLINE QT CAN BE PREDICTED BY ARTERIAL STIFFNESS AND INCREASED ARTERIAL AGE
Introduction: A prolonged QT interval predicts sudden cardiac death. Pulse wave velocity (PWV) is a marker of arterial stiffness and subclinical atherosclerosis and predicts, together with an increased arterial age, cardiovascular events. The aim of the present study was to assess the relationship between borderline QT intervals and markers of subclinical atherosclerosis.
Methods: Standard 12 lead ECG and arteriography were performed in 32 patients with normal, high normal and increased blood pressures. QT intervals were automatically measured and pulse wave velocity (PWV), arterial age and diastolic coronary filling parameters (DRA: diastolic reflection area, and DAI: diastolic area index), were assessed.
Results: QTmax (maximal QT interval duration) was 377±27 ms, QTc: 422±29 ms, PWV: 8±1.45 m/s, DAI: 53±5%, DRA: 53±10. Patients with an increased PWV, impaired DRA and DAI and an increased arterial age were more likely to have QTc 440 ms (OR=1.357, 95%CI: 0.202-9.126; 2.72, 95%CI: 0.522-14.165; 2.375, 95%CI: 0.410- 13.748 and 1.235, 95%CI: 0.198-7.673, respectively)
Conclusion: Increased pulse wave velocity, impaired diastolic filling of the left coronary artery and increased arterial age are predictors of borderline QT intervals.