ISSN: 1223-1533

< Return to the list of articles

THE VARIOUS ELECTROCARDIOGRAPHIC AND ECHOCARDIOGRAPHIC CHANGES IN PATIENTS WITH WILSON’S DISEASE: A REPORT OF 60 CASES


Authors: Gui-zhi Liu, Dong-feng Zhang, Yan Zhang, Hua Sun




 

Introduction: Wilson’s disease (WD), a disorder of copper metabolism, results in abnormal accumulation of copper in liver, brain, kidney and cornea giving rise to protean manifestations. Heart involvement in WD, however, has rarely been recognized. The various electrocardiographic and echocardiographic changes in patients with WD were evaluated in this article.

 

Methods: A prospective study was undertaken of 60 consecutive patients (33 men and 27 women, mean age of 22 years) with WD. All subjects underwent complete the resting electrocardiographic and echocardiographic examination in three days after admission.

 

Results: Electrocardiographic abnormalities occurred in 34 of 60 patients (57 percent), including arrhythmia, left ventricular (LV) hypertrophy and LV high voltage, ST depression and T inversion, early repolarization, LV inferior wall abnormal Q wave and prolonged QT interval. Echocardiographic abnormalities occurred in 11 of 60 patients (18 percent), including LV hypertrophy or increased thickness of the interventricular septum and / or LV posterior wall, left atrium hypertrophy, valvular insufficiency or regurgitation and LV diastolic dysfunction. It has good consistency that the changes of electrocardiogram and echocardiogram in patients with WD. There was no statistically significant difference in electrocardiographic and echocardiographic abnormalities with reference to age. But the rate of electrocardiographic and echocardiographic abnormalities was significantly higher in males than in females.

 

Conclusions: Cardiac involvement in WD is not uncommon. The abnormal rates of echocardiogram especially electrocardiogram in patients with WD was significantly high.